This very sophisticated mass spectrometer was built by Dr. John Fenn and his graduate students at Yale University to study Electro-Spray Ionization Mass Spectrometry. This technique ionizes large biological molecules (macromolecules) and then analyzes them with a typical mass spectrometer. Until Fenn invented this instrument, macromolecules were extremely difficult to measure owing to their size and complexity. Dr. Fenn shared the 2002 Nobel Prize in Chemistry with Koichi Tanaka “for their development of soft desorption ionization methods for mass spectrometric analyses of biological macromolecules.”
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Wetzlar microscope, 1920s
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