This model was the first whole-blood glucose analyzer. The instrument directly measures the whole-blood glucose level from a 25-microliter sample within a ±2% accuracy. The sensor created for the Model 23A was the first commercial biosensor and was used in the Miles Biostator, the first artificial pancreas. The U.S. Food and Drug Administration has identified the YSI Model 23A and subsequent designs as the reference standard for measuring glucose.
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