Title and Description Page
Childhood and Family Life 1
Family background. Parents. Siblings. Childhood experiences. Interest in music. Early interest in science. Mathematics courses during high school and college Reasons for pursuing a career in science. Creativity in science.
High School Research, College, and Graduate School 26
Works in Barbara L. Schwartz’s and Stephen M. Schwartz’s laboratories during high school. Attends the University of Washington. Works in E. Theodore Young’s laboratory during his junior year. Influential teachers. Majors in biochemistry after taking a class in recombinant DNA technology. Knowing the evolution of ideas in a scientific field. College life. Attends Stanford University
for his doctoral studies. Graduate program at Stanford. Arthur Kornberg. Biochemistry department at Stanford. Chooses David S. Hogness’s laboratory for his thesis project. Hogness laboratory. Doctoral work on hormonal-controlled development and the hormone receptor for ecdysone. Hogness’s laboratory management style. Significance of Koelle’s work.
Postdoctoral Work at MIT and Current Research 39
Religion. Postdoctoral fellowship in H. Robert Horvitz’s laboratory atMassachusetts Institute of Technology. Horvitz’s management style. A typical day in Horvitz’s laboratory. Research on the genes involved in neural function and on the mechanics of neurotransmission. Broader applications of his work. Multimodal approach to problem solving. Broader applications of work. Current
research on G protein signaling and its regulation to study the mechanism of neurotransmission. Accepts a position at Yale University. Reasons for choosing to work at Yale. Setting up lab. Research grants. Meets his future wife.
Life Inside and Outside of the Lab 74
Parental expectations. Serendipity. Role in the lab. Teaching responsibilities. Travel commitments. Administrative duties. Funding history. Funding. Writing journal articles. Laboratory management style. Running his laboratory. Professional community. Tenure. Balancing family and career. Leisure activities. A typical workday. Success in achieving professional goals. Qualities of a good scientist. Future research on the molecular mechanisms of neurotransmission and of controlled cell division in embryogenesis. Patents. Intellectual property. Privatization of scientific research. Reasons for becoming a principal investigator.
Final Thoughts 99
Criteria for choosing research projects. Role of the scientist in educating the public about science. National scientific agenda. Gender. Pew Scholars Program in the Biomedical Sciences.