Crime? It’s as old as history. Detecting crime? Only as old as science. And when it comes to poison most foul, the 19th century is when you want to go. Real forensics began during that century, and much of the credit belongs to a transplanted Spaniard. Mateu Orfila created the first work of forensic toxicology, Traité des Poisons, which was first published in 1814 (and is now living a blameless life in CHF’s rare books collection). Orfila’s pursuit of justice through forensics made corpses of many animals. Orfila fed his lab animals different poisons, watched the often painful results, and then dissected the bodies to find out how the poisons killed.