Marie Maynard Daly

Marie Maynard Daly

Marie Maynard Daly. Queens College Silhouette Yearbook, 1942. Courtesy Queens College.

The early research of Marie Maynard Daly (1921–2003) included studies of the effects of cholesterol on the mechanics of the heart, the effects of sugars and other nutrients on the health of arteries, and the breakdown of the circulatory system as a result of advanced age or hypertension. Later she studied how proteins are produced and organized in the cell.

Daly overcame dual hurdles of racial and gender bias to pursue chemistry. Born in the Corona neighborhood of Queens, New York, she was an avid reader and was fascinated by Paul De Kruif’s popular book The Microbe Hunters. She was further inspired by her father’s love of science. Unfortunately, he had been forced by economic circumstances to drop out of Cornell University, where he had been pursuing a bachelor’s degree in chemistry.

Daly was educated at Hunter College High School, an all-female institution, where her ambition to become a chemist was supported and encouraged. She enrolled in Queens College in Flushing, New York, as a commuting student, and graduated magna cum laude in 1942 with a bachelor’s degree in chemistry. The college offered her a fellowship to pursue graduate studies in chemistry at New York University while working part-time as a laboratory assistant at Queens College. In just one year she completed her master’s degree.

Daly enrolled in the doctoral program at Columbia University after working for a year tutoring chemistry students at Queens College. She also obtained funding from the university to help in her full-time study of chemistry. Under the direction of Mary L. Caldwell, who was known for her work on the important digestive enzyme amylase, Daly researched how compounds produced in the body affect and participate in digestion. The title of her dissertation was “A Study of the Products Formed by the Action of Pancreatic Amylase on Corn Starch.” She was awarded her doctoral degree in 1947, only three years after enrolling in the program, and was the first African American woman to obtain a Ph.D. in chemistry in the United States.

After completing her doctoral degree, Daly taught for two years at Howard University in Washington, D.C. On receiving a grant from the American Cancer Society to support her postdoctoral research, she joined Alfred E. Mirsky, a pioneer in molecular biology, at the Rockefeller Institute in New York, where for seven years she worked on the composition and metabolism of components of the cell nucleus, among other studies. Then Daly took a new position teaching biochemistry at the College of Physicians and Surgeons of Columbia University. In 1960 she became a professor at the Albert Einstein College of Medicine, where she remained until her retirement in 1986. In 1961 she married Vincent Clark.

In addition to her research Daly was committed to developing programs to increase the enrollment of minority students in medical school and graduate science programs. In 1988 she established a scholarship fund for African American science students at Queens College in honor of her father.

Catalyst Series: Women in Chemistry

Women in Chemistry

Follow the adventures of eight leading women in chemistry and celebrate their life-changing, chance-taking, thrill-seeking love of science. 

Hear It Firsthand

The Center for Oral History captures and preserves the stories of notable figures in chemistry and related fields, with over 425 oral histories that deal with various aspects of science, of scientists, and of scientific practices. For more information please visit CHF’s Oral History Program or e-mail oralhistory@

Connect with CHF


Distillations Podcast logo
Listen to the latest episodes of CHF’s award-winning podcast.

Historically Grounded Perspectives

The Center for Contemporary History and Policy explores issues ranging from energy to medicine on CHF's blog, Periodic Tabloid.